Gene silencing of the p15/INK4B cell-cycle inhibitor by hypermethylation: an early or later epigenetic alteration in myelodysplastic syndromes?

Leukemia. 2003 Sep;17(9):1762-4. doi: 10.1038/sj.leu.2403045.

Author

M Lübbert¹

Affiliation

¹ Department Internal Medicine I, Division of Hematology/Oncology, University of Freiburg Medical Center, Freiburg, Germany. luebbert@mm11.ukl.uni-freiburg.de

PMID: 12970776
DOI: 10.1038/sj.leu.2403045

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Review
Comment

MeSH terms

Cell Cycle
Cell Cycle Proteins / genetics*
CpG Islands
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16 / genetics*
DNA (Cytosine-5-)-Methyltransferases / metabolism
DNA Methylation*
Enzyme Inhibitors
Gene Silencing*
Genes, Tumor Suppressor
Humans
Myelodysplastic Syndromes / genetics*
Tumor Suppressor Proteins*

Substances

CDKN2B protein, human
Cell Cycle Proteins
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Enzyme Inhibitors
Tumor Suppressor Proteins
DNA (Cytosine-5-)-Methyltransferases