The expression of the EBV latent membrane protein (LMP-1) is independent of CD23 and bcl-2 in Reed-Sternberg cells in Hodgkin's disease

Histopathology. 1992 Jul;21(1):72-3. doi: 10.1111/j.1365-2559.1992.tb00346.x.

Abstract

A series of 33 cases of Hodgkin's disease was investigated for the presence of the EBV encoded latent gene product LMP-1 and of CD23 using immunohistochemical techniques. The expression of bcl-2 was examined in a subset of cases. LMP-1 was detected in the Reed-Sternberg cells in 15 cases. Although LMP-1 is known to upregulate CD23 and bcl-2, there was no correlation between the expression of LMP-1 and the detection of CD23 and bcl-2 in Reed-Sternberg cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD / analysis
  • Antigens, Differentiation, B-Lymphocyte / analysis
  • Antigens, Neoplasm / analysis
  • Antigens, Viral / analysis*
  • Herpesvirus 4, Human / immunology*
  • Hodgkin Disease / immunology
  • Hodgkin Disease / microbiology*
  • Humans
  • Immunoenzyme Techniques
  • Middle Aged
  • Proto-Oncogene Proteins / analysis
  • Proto-Oncogene Proteins c-bcl-2
  • Receptors, Fc / analysis
  • Receptors, IgE
  • Reed-Sternberg Cells / immunology*
  • Reed-Sternberg Cells / microbiology
  • Tumor Virus Infections / immunology*
  • Viral Matrix Proteins*

Substances

  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • Antigens, Neoplasm
  • Antigens, Viral
  • EBV-associated membrane antigen, Epstein-Barr virus
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Receptors, Fc
  • Receptors, IgE
  • Viral Matrix Proteins