Abstract
A series of 33 cases of Hodgkin's disease was investigated for the presence of the EBV encoded latent gene product LMP-1 and of CD23 using immunohistochemical techniques. The expression of bcl-2 was examined in a subset of cases. LMP-1 was detected in the Reed-Sternberg cells in 15 cases. Although LMP-1 is known to upregulate CD23 and bcl-2, there was no correlation between the expression of LMP-1 and the detection of CD23 and bcl-2 in Reed-Sternberg cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Antigens, CD / analysis
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Antigens, Differentiation, B-Lymphocyte / analysis
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Antigens, Neoplasm / analysis
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Antigens, Viral / analysis*
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Herpesvirus 4, Human / immunology*
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Hodgkin Disease / immunology
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Hodgkin Disease / microbiology*
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Humans
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Immunoenzyme Techniques
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Middle Aged
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Proto-Oncogene Proteins / analysis
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Proto-Oncogene Proteins c-bcl-2
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Receptors, Fc / analysis
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Receptors, IgE
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Reed-Sternberg Cells / immunology*
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Reed-Sternberg Cells / microbiology
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Tumor Virus Infections / immunology*
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Viral Matrix Proteins*
Substances
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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Antigens, Neoplasm
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Antigens, Viral
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EBV-associated membrane antigen, Epstein-Barr virus
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Receptors, Fc
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Receptors, IgE
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Viral Matrix Proteins