Effects of concentration reduction and partial replacement of paraquat by diquat on human toxicity: a clinical survey

Hum Exp Toxicol. 1992 Jul;11(4):241-5. doi: 10.1177/096032719201100401.

Abstract

Paraquat poisoning was studied in 174 patients over a 12-month period when a new, low concentration paraquat product (4.5% w/v paraquat ion mixed with 4.5% w/v diquat ion; 63 cases) replaced the original high concentration paraquat product (20% w/v paraquat ion only; 111 cases). In both groups approximately 60% of the patients died from circulatory failure accompanied by multiple organ failure within a week of ingesting the products. However, a remarkable reduction in late deaths from respiratory failure was noted in the new product group (17.1% vs 6.3%). This was reflected in this group's improved survival (23.4% vs 34.9%). The improvement in survival seems to be attributable to the dilution of paraquat with diquat which seems to have a different toxicological profile to paraquat.

MeSH terms

  • Blood Urea Nitrogen
  • Chromatography, High Pressure Liquid
  • Diquat / blood
  • Diquat / poisoning*
  • Humans
  • Multiple Organ Failure / chemically induced
  • Paraquat / blood
  • Paraquat / poisoning*
  • Poisoning / mortality
  • Respiratory Function Tests
  • Respiratory Insufficiency / chemically induced
  • Shock / chemically induced

Substances

  • Diquat
  • Paraquat