Abstract
Virus-specific T cell-mediated immunity was investigated in healthy sheep persistently infected with the ruminant lentivirus maedi-visna. Visna-specific lymphocyte proliferation was demonstrated in response to both purified virions and recombinant p25, the major core protein of maedi-visna virus. The responding T cell population in this assay was mainly of the CD4+ phenotype, although in some individuals CD8+ T cells were also shown to respond to visna antigen in this system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / immunology
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CD8 Antigens / immunology
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Immunity, Cellular*
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Lymphocyte Activation / drug effects
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Lymphocyte Activation / immunology
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Pneumonia, Progressive Interstitial, of Sheep / immunology*
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Recombinant Proteins / immunology
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Recombinant Proteins / pharmacology
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Sheep
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T-Lymphocytes / immunology*
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Viral Core Proteins / immunology
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Viral Core Proteins / pharmacology
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Virion / immunology
Substances
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CD8 Antigens
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Recombinant Proteins
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Viral Core Proteins