Abstract
Rats were trained on a spatial delayed-nonmatching-to-sample (DNMTS) task and assigned by block randomization to one of four treatments: pyrithiamine-induced thiamine deficiency (PTD), PTD with administration of MK-801 after 12 days, control with MK-801 treatment, and control without MK-801. After 15 days of treatment followed by 21 days of recovery, the PTD rats showed significant deficits for DNMTS accuracy at retention intervals (RI) that ranged from 3.0 s to 15.0 s, the RIs that produced 75% accuracy on DNMTS in staircase training, and the rate at which a novel radial arm maze task was learned. The PTD-treated rats had consistent lesions in the thalamus and the mammillary bodies. MK-801 protected rats from both behavioral deficits and brain lesions (assessed quantitatively and qualitatively) that were produced by the PTD treatment.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alcohol Amnestic Disorder / physiopathology*
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Animals
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Appetitive Behavior / drug effects
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Appetitive Behavior / physiology
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Brain Mapping
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Discrimination Learning / drug effects*
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Discrimination Learning / physiology
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Dizocilpine Maleate / pharmacology*
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Male
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Mental Recall / drug effects*
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Mental Recall / physiology
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Orientation / drug effects*
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Orientation / physiology
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Pyrithiamine / antagonists & inhibitors
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Pyrithiamine / toxicity*
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Rats
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Reaction Time / drug effects
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Reaction Time / physiology
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Receptors, N-Methyl-D-Aspartate / drug effects*
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Receptors, N-Methyl-D-Aspartate / physiology
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Retention, Psychology / drug effects
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Retention, Psychology / physiology
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Thalamus / drug effects
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Thalamus / physiopathology
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Thiamine Deficiency / chemically induced*
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Thiamine Deficiency / physiopathology
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Wernicke Encephalopathy / chemically induced*
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Wernicke Encephalopathy / physiopathology
Substances
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Receptors, N-Methyl-D-Aspartate
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Pyrithiamine
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Dizocilpine Maleate