Abstract
A case of myelofibrosis in association with systemic lupus erythematosus (SLE) is reported. Acute thrombocytopenia and a bleeding tendency developed in a 24-year-old woman with SLE. Bone marrow aspiration was unsuccessful due to myelofibrosis. Pulse therapy with methylprednisolone reversed both thrombocytopenia and myelofibrosis. A review of the literature revealed that the coexistence of SLE and myelofibrosis is a rare occurrence. Only 7 cases, to our knowledge, have ever been reported in detail. The present case is the 3rd in which myelofibrosis was reversed by corticosteroids.
MeSH terms
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Adult
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Anemia / drug therapy
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Anemia / etiology
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Anemia / pathology
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Biopsy
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Bone Marrow / pathology
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Female
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Hemorrhagic Disorders / drug therapy
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Hemorrhagic Disorders / etiology
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Hemorrhagic Disorders / pathology
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Humans
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Lupus Erythematosus, Systemic / complications
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Lupus Erythematosus, Systemic / drug therapy*
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Lupus Erythematosus, Systemic / pathology
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Methylprednisolone / administration & dosage*
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Primary Myelofibrosis / drug therapy*
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Primary Myelofibrosis / etiology
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Primary Myelofibrosis / pathology
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Thrombocytopenia / drug therapy
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Thrombocytopenia / etiology
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Thrombocytopenia / pathology