SHP-1 sensitizes MCF-7 cells to trichostatin A-induced apoptosis by modulating PI3K-dependent events

Cell Death Differ. 2003 Oct;10(10):1213-4. doi: 10.1038/sj.cdd.4401292.
No abstract available

Publication types

  • Letter

MeSH terms

  • Analysis of Variance
  • Apoptosis / drug effects
  • Apoptosis / physiology*
  • Carrier Proteins / metabolism
  • Caspase 7
  • Caspase 9
  • Caspases / metabolism
  • Cell Line, Tumor / drug effects
  • Cell Line, Tumor / metabolism
  • Flow Cytometry
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Hydroxamic Acids / pharmacology*
  • Immunoblotting
  • Intracellular Signaling Peptides and Proteins
  • Mutation, Missense
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Phosphorylation
  • Protein Serine-Threonine Kinases*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • Protein Tyrosine Phosphatases / genetics
  • Protein Tyrosine Phosphatases / metabolism*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-akt
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Transfection
  • bcl-2-Associated X Protein
  • bcl-Associated Death Protein

Substances

  • BAD protein, human
  • Carrier Proteins
  • Hydroxamic Acids
  • Intracellular Signaling Peptides and Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • bcl-2-Associated X Protein
  • bcl-Associated Death Protein
  • trichostatin A
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • PTPN6 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • Protein Tyrosine Phosphatases
  • CASP7 protein, human
  • CASP9 protein, human
  • Caspase 7
  • Caspase 9
  • Caspases