Structure and functions of tumor necrosis factor-alpha converting enzyme

Acta Biochim Pol. 2003;50(3):625-45.

Abstract

Tumor necrosis factor-alpha converting enzyme (TACE) is the first described and best characterized secretase. In this review the structure and the possible roles for TACE are summarized. The substrate specificity and the regulation of TACE activity as well as redundancy and possible cooperations of distinct secretases are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ADAM Proteins
  • ADAM17 Protein
  • Animals
  • Enzyme Activation / physiology
  • Metalloendopeptidases / genetics
  • Metalloendopeptidases / metabolism*
  • Metalloproteases / genetics
  • Metalloproteases / metabolism*
  • Mice
  • Mice, Knockout
  • Protein Structure, Secondary / genetics
  • Protein Structure, Secondary / physiology
  • Substrate Specificity / physiology

Substances

  • Metalloproteases
  • ADAM Proteins
  • Metalloendopeptidases
  • ADAM17 Protein
  • Adam17 protein, mouse