Synthesis of dinucleoside boranophosphates by a boranophosphotriester approach

Takeshi Wada; Mamoru Shimizu; Natsuhisa Oka; Kazuhiko Saigo

doi:10.1081/NCN-120022828

Synthesis of dinucleoside boranophosphates by a boranophosphotriester approach

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1171-3. doi: 10.1081/NCN-120022828.

Authors

Takeshi Wada¹, Mamoru Shimizu, Natsuhisa Oka, Kazuhiko Saigo

Affiliation

¹ Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan. wada@k.u.tokyo.ac.jp

PMID: 14565372
DOI: 10.1081/NCN-120022828

Abstract

Dinucleoside boranophosphates including four kinds of nucleobases were synthesized by a boranophosphotriester method in good yields. In the present boranophosphotriester method, side-reactions at the nucleobases, which caused by a borane reagent, were completely avoided.

MeSH terms

Boron Compounds*
Indicators and Reagents
Nucleosides / chemistry
Oligodeoxyribonucleotides / chemical synthesis*
Oligodeoxyribonucleotides / chemistry
Oligonucleotides, Antisense / chemical synthesis

Substances

Boron Compounds
Indicators and Reagents
Nucleosides
Oligodeoxyribonucleotides
Oligonucleotides, Antisense
dinucleoside dimers