Cl- sensitive biosensor used electrolyte-solution-gate diamond FETs

Biosens Bioelectron. 2003 Nov 15;19(2):137-40. doi: 10.1016/s0956-5663(03)00174-x.

Abstract

We have investigated the electrolyte-solution-gate field effect transisitors (SGFETs) used hydrogen terminated (H-terminated) or partially oxygen terminated (O-terminated) polycrystalline diamond surface in the Cl- and Br- ionic solutions. The H-terminated channel SGFETs are insensitive to pH values in electrolyte solutions. The threshold voltages of the diamond SGFETs shift according to the density of Cl- and Br- ions about 30 mV/decade. One of the attractive biomedical applications for the Cl- sensitive SGFETs is the detection of chloride density in blood or in sweat especially in the case of cystic fibrosis. The sensitivities of Cl- and Br- ions have been lost on the partially O-terminated diamond surface. These phenomena can be explained by the polarity of surface change on the H-terminated and the O-terminated surface.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Biosensing Techniques / instrumentation*
  • Biosensing Techniques / methods*
  • Chlorine / analysis*
  • Chlorine / chemistry*
  • Diamond / chemistry*
  • Electrochemistry / instrumentation*
  • Electrochemistry / methods*
  • Electrolytes / chemistry
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Transistors, Electronic

Substances

  • Electrolytes
  • Chlorine
  • Diamond