Photodynamic endometrial ablation for the treatment of dysfunctional uterine bleeding: a preliminary report

Lasers Surg Med. 2004;34(1):1-4. doi: 10.1002/lsm.10244.

Abstract

Background and objectives: To evaluate feasibility and functional effects of photodynamic endometrial ablation (PEA) in patients.

Study design/patients and methods: A total of 15 PEAs has been performed in 11 patients using topically applied 5-aminolevulinic acid (ALA) solutions and a balloon-light diffuser (160 J/cm(2), 635 nm). Uterine bleeding intensity has been determined on a daily basis 3 months prior to and up to 6 months after endometrial ablation using an analogous scale scoring from 1 (spotting) to 6 U (severe bleeding). Statistical analysis by unpaired Student's t-test.

Results: The mean number of bleeding units per cycle (n = 44) was 35.7 prior to PEA. The decrease in bleeding units was significant for the months 1-3 (24.4 U per cycle; P = 0.03), but not for the months 4-6 (25.9 U; P = 0.11) following PEA.

Conclusions: PEA is feasible and provides a significant short-term reduction of uterine bleeding.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aminolevulinic Acid / therapeutic use
  • Catheter Ablation
  • Combined Modality Therapy
  • Feasibility Studies
  • Female
  • Humans
  • Laser Therapy*
  • Middle Aged
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use
  • Uterine Hemorrhage / therapy*

Substances

  • Photosensitizing Agents
  • Aminolevulinic Acid