Abstract
Circulating levels of HDL cholesterol are inversely related to the risk of atherosclerosis, and therapeutic increases in HDL reduce the incidence of cardiovascular events. A new study shows that HDL-associated lysophospholipids stimulate the production of the potent antiatherogenic signaling molecule NO by the vascular endothelium.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Arteriosclerosis / metabolism
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Cholesterol, HDL / metabolism*
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Endothelium, Vascular / metabolism*
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Humans
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Nitric Oxide / metabolism*
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Nitric Oxide Synthase / metabolism
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Nitric Oxide Synthase Type III
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Signal Transduction / physiology
Substances
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Cholesterol, HDL
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Nitric Oxide
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NOS3 protein, human
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type III