Abstract
CD1d molecules are lipid antigen-presenting molecules. They are involved in presenting these antigens to a unique subpopulation of T cells called natural killer T (NKT) cells, which have the capacity to produce both T helper (Th) 1 and Th2 cytokines. Thus, it is possible that the antigens presented by CD1d and/or the level at which they are presented could have profound effects on the immunoregulation of autoimmune and infectious diseases, as well as cancer. Because of the ability of CD1d-binding ligands to modulate NKT cell responses, targeting CD1d-mediated antigen presentation as a novel approach for new therapies in these and other diseases holds great promise.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Antigen Presentation*
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Antigens, CD1 / chemistry
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Antigens, CD1 / genetics
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Antigens, CD1 / metabolism*
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Antigens, CD1d
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Autoimmune Diseases / drug therapy
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Bacterial Infections / immunology
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Cytokines / biosynthesis
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Glycolipids / immunology
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Glycolipids / therapeutic use
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Humans
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Infections / drug therapy
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Killer Cells, Natural / immunology*
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Mice
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Models, Immunological
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Molecular Sequence Data
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Neoplasms / drug therapy
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Neoplasms / immunology
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T-Lymphocyte Subsets / immunology*
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Tyrosine / chemistry
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Virus Diseases / immunology
Substances
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Antigens, CD1
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Antigens, CD1d
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CD1D protein, human
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Cytokines
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Glycolipids
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Tyrosine