Abstract
Bovine viral diarrhea virus (BVDV) is one of the major immuno-suppressive viruses of cattle. The effect on the innate and acquired immune system is unique and results in dramatic immune dysfunction. BVDV infection also has the ability to cause persistent infection (PI) in the developing fetus. This Pl syndrome creates a requirement for high levels of BVDV immunity from vaccines to prevent these infections. BVDV vaccines and their future development continue to be an enigma in the control of BVDV.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Antibodies, Viral / biosynthesis
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Antibodies, Viral / immunology
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Antigens, Viral / immunology
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Bovine Virus Diarrhea-Mucosal Disease / immunology*
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Bovine Virus Diarrhea-Mucosal Disease / prevention & control
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Bovine Virus Diarrhea-Mucosal Disease / virology*
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Cattle
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Diarrhea Viruses, Bovine Viral / immunology*
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Immunity, Cellular
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Immunity, Innate
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Immunity, Maternally-Acquired
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Macrophages / virology
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Viral Vaccines / immunology
Substances
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Antibodies, Viral
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Antigens, Viral
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Viral Vaccines