Abstract
Acute poisoning with tetrachloromethane in a dose of 0.75 LD(50) suppressed humoral and cell immune reactions in Wistar rats. Immunotoxicity of tetrachloromethane is realized via initiation of lipid peroxidation and inhibition of acetylcholine esterase in T lymphocytes and alpha-naphthyl AS-acetate esterase and alpha-naphthyl butyrate esterase in splenocytes.
MeSH terms
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Animals
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B-Lymphocytes / drug effects
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Carbon Tetrachloride / toxicity*
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Carbon Tetrachloride Poisoning / immunology*
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Carbon Tetrachloride Poisoning / metabolism
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Esterases / analysis
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Esterases / drug effects
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Immune System / drug effects*
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Lipid Peroxidation / drug effects
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Rats
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T-Lymphocytes / drug effects*
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T-Lymphocytes / enzymology
Substances
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Carbon Tetrachloride
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Esterases