Abstract
The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Biological Factors / chemical synthesis
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Biological Factors / chemistry
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Epothilones / chemical synthesis*
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Epothilones / chemistry
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Macrolides / chemical synthesis
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Macrolides / chemistry
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Molecular Structure
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Polymers / chemistry
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Stereoisomerism
Substances
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Antineoplastic Agents
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Biological Factors
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Epothilones
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Macrolides
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Polymers
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epothilone C