Abstract
Pbx and Meis proteins act as cofactors to various transcription factors, but their exact functions have been unclear. A report by Berkes et al. in Molecular Cell now demonstrates that Pbx and Meis may penetrate repressive chromatin to mark specific genes for activation.
MeSH terms
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Animals
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Gene Expression Regulation, Developmental / genetics*
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Genes, Homeobox / genetics
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Genes, Regulator / genetics*
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Homeodomain Proteins / genetics*
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Homeodomain Proteins / metabolism
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Humans
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Myeloid Ecotropic Viral Integration Site 1 Protein
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Neoplasm Proteins / genetics*
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Neoplasm Proteins / metabolism
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Pre-B-Cell Leukemia Transcription Factor 1
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Promoter Regions, Genetic / genetics
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Protein Binding / genetics
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins / metabolism
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Repressor Proteins / genetics
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Repressor Proteins / metabolism
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Transcriptional Activation / genetics*
Substances
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DNA-Binding Proteins
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Homeodomain Proteins
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Myeloid Ecotropic Viral Integration Site 1 Protein
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Neoplasm Proteins
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Pre-B-Cell Leukemia Transcription Factor 1
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Proto-Oncogene Proteins
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Repressor Proteins
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PBX1 protein, human