PbX marks the spot

Dev Cell. 2004 Jun;6(6):737-8. doi: 10.1016/j.devcel.2004.05.015.

Abstract

Pbx and Meis proteins act as cofactors to various transcription factors, but their exact functions have been unclear. A report by Berkes et al. in Molecular Cell now demonstrates that Pbx and Meis may penetrate repressive chromatin to mark specific genes for activation.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation, Developmental / genetics*
  • Genes, Homeobox / genetics
  • Genes, Regulator / genetics*
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / metabolism
  • Humans
  • Myeloid Ecotropic Viral Integration Site 1 Protein
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / metabolism
  • Pre-B-Cell Leukemia Transcription Factor 1
  • Promoter Regions, Genetic / genetics
  • Protein Binding / genetics
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins / metabolism
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism
  • Transcriptional Activation / genetics*

Substances

  • DNA-Binding Proteins
  • Homeodomain Proteins
  • Myeloid Ecotropic Viral Integration Site 1 Protein
  • Neoplasm Proteins
  • Pre-B-Cell Leukemia Transcription Factor 1
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • PBX1 protein, human