Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation

Sung-Yu Hong; Kwang-Hoe Chung; Hea-Jung You; Ik Hwa Choi; Mi Jin Chae; Ja-Young Han; Ok-Jai Jung; Soo-Jung Kang; Chung-Kyu Ryu

doi:10.1016/j.bmcl.2004.04.051

Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3563-6. doi: 10.1016/j.bmcl.2004.04.051.

Authors

Sung-Yu Hong¹, Kwang-Hoe Chung, Hea-Jung You, Ik Hwa Choi, Mi Jin Chae, Ja-Young Han, Ok-Jai Jung, Soo-Jung Kang, Chung-Kyu Ryu

Affiliation

¹ College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea.

PMID: 15177474
DOI: 10.1016/j.bmcl.2004.04.051

Abstract

A series of 6-arylamino-5-chloro-benzimidazole-4,7-diones were synthesized and tested for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. Among them, 6-arylamino-5-chloro-2-methyl-benzimidazole-4,7-diones exhibited potent antiproliferative activity. Benzimidazole-4,7-dione 2c activated SAPK/JNK signaling pathway in the RAoSMCs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzimidazoles / chemical synthesis*
Benzimidazoles / pharmacology
Cell Division / drug effects*
Cells, Cultured
Growth Inhibitors / chemical synthesis*
Growth Inhibitors / metabolism
Growth Inhibitors / pharmacology
Inhibitory Concentration 50
JNK Mitogen-Activated Protein Kinases / metabolism
Muscle, Smooth, Vascular / cytology
Muscle, Smooth, Vascular / drug effects*
Muscle, Smooth, Vascular / metabolism
Platelet-Derived Growth Factor / metabolism
Rats
Signal Transduction / drug effects

Substances

Benzimidazoles
Growth Inhibitors
Platelet-Derived Growth Factor
JNK Mitogen-Activated Protein Kinases