Abstract
Supramolecular chemistry at the single-molecule level. An α-hemolysin transmembrane pore can be threaded in a desired orientation by DNA-PEG hybrid strands to yield functional rotaxanes. The single-molecule rotaxanes display stable and reversible two-state switching capacity depending on the applied potential, orientation, and the method of threading and capture used.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Base Sequence
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Cell Membrane / chemistry
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DNA, Single-Stranded / chemistry*
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DNA, Single-Stranded / metabolism
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Hemolysin Proteins / chemistry*
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Hemolysin Proteins / metabolism
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Membrane Transport Proteins / chemistry*
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Molecular Sequence Data
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Polyethylene Glycols / chemistry*
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Polyethylene Glycols / metabolism
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Rotaxanes / chemistry*
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Rotaxanes / metabolism
Substances
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DNA, Single-Stranded
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Hemolysin Proteins
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Membrane Transport Proteins
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Rotaxanes
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Polyethylene Glycols