Abstract
Amiodarone-induced thyrotoxicosis (AIT) is a well-known complication of amiodarone treatment found in 3% to 12% of patients. Two types of AIT have been described, each associated with a distinct histologic pattern of thyroid involvement. Type 1, which typically develops in the background of pre-existing thyroid disease, is due to iodine-induced excess thyroid hormone synthesis, whereas type 2 is due to destructive thyroiditis. The prevalence of thyroid cancer in patients with AIT is unknown. We report a case of papillary thyroid carcinoma associated with type 2 AIT.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amiodarone / adverse effects*
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Anti-Arrhythmia Agents / adverse effects*
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Carcinoma, Papillary, Follicular / etiology
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Carcinoma, Papillary, Follicular / genetics
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Carcinoma, Papillary, Follicular / pathology*
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Mutation
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Thyroid Neoplasms / etiology
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Thyroid Neoplasms / genetics
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Thyroid Neoplasms / pathology*
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Thyrotoxicosis / chemically induced
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Thyrotoxicosis / complications
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Thyrotoxicosis / pathology*
Substances
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Anti-Arrhythmia Agents
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Amiodarone