Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53

Cell. 2004 Jul 9;118(1):2-4. doi: 10.1016/j.cell.2004.06.015.

Abstract

The tumor suppressor and transcriptional regulator p53 is perhaps one of the most regulated proteins in the cell nucleus and is acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-conjugating enzymes. Now new work suggests a role for an additional modification-neddylation-in negative regulation of p53 transcriptional activity.

Publication types

  • Comment

MeSH terms

  • Catalysis
  • Cell Line
  • DNA Damage
  • Ligases / metabolism*
  • Lysine / metabolism
  • Models, Biological
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-mdm2
  • Transcriptional Activation
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*
  • Ubiquitin / genetics
  • Ubiquitin / metabolism*
  • Ultraviolet Rays

Substances

  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53
  • Ubiquitin
  • Proto-Oncogene Proteins c-mdm2
  • Ligases
  • Lysine