Acetyl-L-carnitine dietary supplementation to old rats increases mitochondrial transcription factor A content in rat hindlimb skeletal muscles

V Pesce; F Fracasso; C Musicco; A M S Lezza; P Cantatore; M N Gadaleta

doi:10.1196/annals.1297.077

Acetyl-L-carnitine dietary supplementation to old rats increases mitochondrial transcription factor A content in rat hindlimb skeletal muscles

Ann N Y Acad Sci. 2004 Jun:1019:430-3. doi: 10.1196/annals.1297.077.

Authors

V Pesce¹, F Fracasso, C Musicco, A M S Lezza, P Cantatore, M N Gadaleta

Affiliation

¹ Department of Biochemistry and Molecular Biology, University of Bari, Italy.

PMID: 15247059
DOI: 10.1196/annals.1297.077

Abstract

Acetyl-L-carnitine (ALCAR) fed to old rats has been reported to partially restore mitochondrial function and ambulatory activity. The results of the effect of ALCAR dietary supplementation to 28-month-old rats on mitochondrial transcription factor A (TFAM) content of rat hindlimb skeletal muscles are reported.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylcarnitine / pharmacology*
Animals
DNA, Mitochondrial / metabolism
Dietary Supplements*
Hindlimb / metabolism*
Muscle, Skeletal / metabolism*
Rats
Signal Transduction
Time Factors
Transcription Factors / biosynthesis*

Substances

DNA, Mitochondrial
Tfam protein, rat
Transcription Factors
Acetylcarnitine