Novel (3,5-di-tert-butyl-2-hydroxy-phenylcarbamoyl)-alkanoic acids as potent antioxidants

Vladimir I Lodyato; Irina L Yurkova; Viktor L Sorokin; Oleg I Shadyro; Vladimir I Dolgopalets; Mikhail A Kisel

doi:10.1016/j.bmcl.2004.06.003

Novel (3,5-di-tert-butyl-2-hydroxy-phenylcarbamoyl)-alkanoic acids as potent antioxidants

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4253-6. doi: 10.1016/j.bmcl.2004.06.003.

Authors

Vladimir I Lodyato¹, Irina L Yurkova, Viktor L Sorokin, Oleg I Shadyro, Vladimir I Dolgopalets, Mikhail A Kisel

Affiliation

¹ Department of Chemistry of the Belarusian State University, Skaryna av., 4, 220050 Minsk, Belarus.

PMID: 15261281
DOI: 10.1016/j.bmcl.2004.06.003

Abstract

A series of novel phenolic antioxidants of amphiphilic structure has been synthesized. Investigations into the influence of aliphatic spacer length and nature of a hydrophilic anchor on the antioxidant activity allowed elucidating certain structure requirements for the membrane-addressed antioxidant designing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkanes / chemistry*
Alkanes / pharmacology*
Antioxidants / chemistry*
Antioxidants / pharmacology*
Molecular Structure
Structure-Activity Relationship

Substances

Alkanes
Antioxidants