Diterpenes from the brown algae Dictyota dichotoma and Dictyota linearis

Panayiota Siamopoulou; Antonis Bimplakis; Dimitra Iliopoulou; Constantinos Vagias; Paul Cos; Dirk Vanden Berghe; Vassilios Roussis

doi:10.1016/j.phytochem.2004.06.018

Diterpenes from the brown algae Dictyota dichotoma and Dictyota linearis

Phytochemistry. 2004 Jul;65(14):2025-30. doi: 10.1016/j.phytochem.2004.06.018.

Authors

Panayiota Siamopoulou¹, Antonis Bimplakis, Dimitra Iliopoulou, Constantinos Vagias, Paul Cos, Dirk Vanden Berghe, Vassilios Roussis

Affiliation

¹ Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Athens, Panepistimioupolis Zografou, 157 71 Athens, Greece.

PMID: 15279967
DOI: 10.1016/j.phytochem.2004.06.018

Abstract

Nineteen secondary metabolites of the brown alga Dictyota dichotoma (Huds.) Lam. and fifteen metabolites of the brown alga D. linearis (Ag.) Grev. were isolated and their chemical structures were elucidated on the basis of their NMR and mass spectral data. The diterpenes isopachydictyolal (1) from D. dichotoma and 4alpha-acetyldictyodial (2) from D. linearis are new natural products. The antiviral activity of metabolites isolated in adequate amounts was evaluated in laboratory assays against Herpes simplex virus I (HSV I) and Poliomyelitis Virus I, using Vero cells as hosts.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / chemistry
Chromatography, High Pressure Liquid
Diterpenes / chemistry
Diterpenes / isolation & purification*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Phaeophyceae / chemistry*

Substances

Antiviral Agents
Diterpenes