Biosynthesis of cervimycin C, an aromatic polyketide antibiotic bearing an unusual dimethylmalonyl moiety

Org Biomol Chem. 2004 Sep 7;2(17):2411-4. doi: 10.1039/B409221J. Epub 2004 Aug 4.

Abstract

Cervimycin C is the major component of an antibiotic complex produced by Streptomyces tendae HKI-179 consisting of a tetracycline-type aglycon, six tridesoxysugars and a rare dimethylmalonyl moiety. The biosynthetic origin of cervimycin was studied by molecular studies and feeding experiments, which reveal that the dimethylmalonate unit is not derived from malonate, but from valine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthracyclines / chemistry
  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / chemistry
  • Carbohydrate Sequence
  • Macrolides / chemistry
  • Macrolides / metabolism*
  • Malonates / chemistry*
  • Molecular Sequence Data
  • Molecular Structure
  • Species Specificity
  • Streptomyces / classification
  • Streptomyces / metabolism*

Substances

  • Anthracyclines
  • Anti-Bacterial Agents
  • Macrolides
  • Malonates
  • cervimycin C
  • methyl malonate