Atypical teratoid/rhabdoid tumour with leptomeningeal dissemination in an adult

Acta Neurochir (Wien). 2004 Sep;146(9):1033-8; discussion 1038. doi: 10.1007/s00701-004-0313-5. Epub 2004 Jun 28.

Abstract

A 22-year-old man presented with a rare case of atypical teratoid/rhabdoid tumour (AT/RT). Magnetic resonance imaging showed a left cerebellar mass with leptomeningeal dissemination. Partial resection was performed. Histological examination revealed AT/RT. Postoperatively, whole neuraxis and local irradiation were performed. Three-drug chemotherapy with ifosfamide, cisplatin, and etoposide, and adjuvant intrathecal administration of methotrexate were repeated. Near complete response was achieved, and no tumour recurrence/progression has been noticed during the follow up of 24 months. Intensive radiochemotherapy can successfully control AT/RT, even with leptomeningeal dissemination.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cerebellar Neoplasms / drug therapy
  • Cerebellar Neoplasms / pathology*
  • Cerebellar Neoplasms / radiotherapy
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Disease Progression
  • Etoposide / administration & dosage
  • Humans
  • Ifosfamide / administration & dosage
  • Magnetic Resonance Imaging
  • Male
  • Meningeal Neoplasms / drug therapy
  • Meningeal Neoplasms / pathology*
  • Meningeal Neoplasms / radiotherapy
  • Methotrexate / administration & dosage
  • Neoplasm Invasiveness
  • Rhabdoid Tumor / drug therapy
  • Rhabdoid Tumor / pathology*
  • Rhabdoid Tumor / radiotherapy
  • Teratoma / drug therapy
  • Teratoma / pathology*
  • Teratoma / radiotherapy

Substances

  • Etoposide
  • Cisplatin
  • Ifosfamide
  • Methotrexate