Abstract
A 22-year-old man presented with a rare case of atypical teratoid/rhabdoid tumour (AT/RT). Magnetic resonance imaging showed a left cerebellar mass with leptomeningeal dissemination. Partial resection was performed. Histological examination revealed AT/RT. Postoperatively, whole neuraxis and local irradiation were performed. Three-drug chemotherapy with ifosfamide, cisplatin, and etoposide, and adjuvant intrathecal administration of methotrexate were repeated. Near complete response was achieved, and no tumour recurrence/progression has been noticed during the follow up of 24 months. Intensive radiochemotherapy can successfully control AT/RT, even with leptomeningeal dissemination.
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Cerebellar Neoplasms / drug therapy
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Cerebellar Neoplasms / pathology*
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Cerebellar Neoplasms / radiotherapy
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Cisplatin / administration & dosage
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Combined Modality Therapy
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Disease Progression
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Etoposide / administration & dosage
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Humans
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Ifosfamide / administration & dosage
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Magnetic Resonance Imaging
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Male
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Meningeal Neoplasms / drug therapy
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Meningeal Neoplasms / pathology*
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Meningeal Neoplasms / radiotherapy
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Methotrexate / administration & dosage
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Neoplasm Invasiveness
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Rhabdoid Tumor / drug therapy
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Rhabdoid Tumor / pathology*
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Rhabdoid Tumor / radiotherapy
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Teratoma / drug therapy
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Teratoma / pathology*
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Teratoma / radiotherapy
Substances
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Etoposide
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Cisplatin
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Ifosfamide
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Methotrexate