Vasculitis associated with the use of leflunomide

Jeannie Macdonald; Toni Zhong; Adriana Lazarescu; Bing Siang Gan; Manfred Harth

Vasculitis associated with the use of leflunomide

J Rheumatol. 2004 Oct;31(10):2076-8.

Authors

Jeannie Macdonald¹, Toni Zhong, Adriana Lazarescu, Bing Siang Gan, Manfred Harth

Affiliation

¹ Department of Medicine, The University of Western Ontario, London, Ontario, Canada.

PMID: 15468379

Abstract

Vasculitis as a complication of leflunomide therapy in the treatment of rheumatoid arthritis has been reported. We describe a case of acute necrotizing vasculitis following leflunomide therapy. Characteristics of this case and 4 cases in the literature suggest that vasculitis may be a rare but serious adverse effect of leflunomide therapy.

Publication types

Case Reports

MeSH terms

Aged
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Arthritis, Rheumatoid / drug therapy
Female
Humans
Isoxazoles / adverse effects*
Isoxazoles / therapeutic use
Leflunomide
Male
Middle Aged
Treatment Outcome
Vasculitis / chemically induced*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Isoxazoles
Leflunomide