Live attenuated influenza vaccine induces cross-reactive antibody responses in children against an a/Fujian/411/2002-like H3N2 antigenic variant strain

Pediatr Infect Dis J. 2004 Nov;23(11):1053-5. doi: 10.1097/01.inf.0000143643.44463.b1.

Abstract

Serum antibody titers against the A/Panama/2007/99(H3N2) and A/Fujian/411/2002(H3N2)-like viruses were determined in children 6-35 months of age who received either 1 dose of the inactivated influenza vaccine or the live attenuated influenza vaccine containing the A/Panama strain. Results indicated that the live vaccine induced higher antibody responses than the inactivated vaccine against the A/Panama and A/Fujian-like viruses.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase II
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Age Factors
  • Antibodies, Viral / analysis
  • Antibodies, Viral / immunology*
  • Antibody Formation / immunology
  • Child, Preschool
  • Female
  • Hemagglutination Inhibition Tests
  • Humans
  • Immunization Schedule
  • Incidence
  • Infant
  • Influenza A Virus, H3N2 Subtype*
  • Influenza A virus / classification*
  • Influenza A virus / immunology*
  • Influenza Vaccines / administration & dosage*
  • Influenza Vaccines / immunology
  • Influenza, Human / epidemiology
  • Influenza, Human / immunology
  • Influenza, Human / prevention & control*
  • Male
  • Probability
  • Risk Assessment
  • Sensitivity and Specificity
  • Sex Factors
  • Statistics, Nonparametric
  • United States / epidemiology
  • Vaccination / methods*
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / immunology

Substances

  • Antibodies, Viral
  • Influenza Vaccines
  • Vaccines, Attenuated