Ocular dominance plasticity may be the paradigmatic in vivo model of activity-dependent plasticity. More than four decades of intense research has delineated the network-level rules that govern synaptic change in this model. The recent characterization of a murine model for ocular dominance plasticity has facilitated rapid progress on a new front, extending our understanding of the molecular mechanisms underlying ocular dominance plasticity. In this review, we highlight recent advances in this research effort, focusing in particular on signaling pathways mediating shifts in ocular dominance, and mechanisms underlying the timing of the critical period.