Abstract
The synthesis of 10 G*PE analogues, wherein the glycine residue has been modified, is described by coupling readily accessible dibenzyl-L-prolyl-L-glutamate 2 with various analogues of glycine. Pharmacological evaluation of the novel compounds was undertaken to further understand the role of the glycine residue on the observed neuroprotective properties of the endogenous tripeptide GPE.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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Corpus Striatum / cytology
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Female
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Glutamic Acid / analogs & derivatives*
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Glutamic Acid / chemical synthesis
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Glutamic Acid / pharmacology
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Glycine / chemistry*
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Models, Chemical
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Molecular Structure
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Neurons / drug effects
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Neuroprotective Agents / chemical synthesis*
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Neuroprotective Agents / pharmacology*
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Okadaic Acid / antagonists & inhibitors
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Oligopeptides / chemical synthesis*
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Oligopeptides / pharmacology*
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Rats
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Rats, Wistar
Substances
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Neuroprotective Agents
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Oligopeptides
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Okadaic Acid
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Glutamic Acid
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Glycine
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glycyl-prolyl-glutamic acid