Abstract
An anionic chiral auxiliary mediated asymmetric alkylation of carbamate 2 provides 3-substituted isoindolinones 4 in high ee. This methodology was used in the first asymmetric synthesis of (+)-lennoxamine.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Crystallography, X-Ray
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Dioxanes / chemical synthesis*
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Heterocyclic Compounds / chemical synthesis*
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Indoles / chemical synthesis*
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Models, Molecular
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Stereoisomerism
Substances
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Dioxanes
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Heterocyclic Compounds
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Indoles
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lennoxamine