Abstract
The authors have developed a class of potent inhibitors against the phosphate specific prolyl isomerase hPin1, which induced apoptosis in transformed cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects*
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Cell Line
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Cell Transformation, Neoplastic / drug effects*
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Enzyme Inhibitors* / chemical synthesis
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Enzyme Inhibitors* / chemistry
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Enzyme Inhibitors* / pharmacology
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Humans
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Molecular Structure
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NIMA-Interacting Peptidylprolyl Isomerase
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Peptidylprolyl Isomerase / antagonists & inhibitors*
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ras Proteins / metabolism*
Substances
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Enzyme Inhibitors
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NIMA-Interacting Peptidylprolyl Isomerase
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ras Proteins
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PIN1 protein, human
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Peptidylprolyl Isomerase