A new therapeutic challenge for old pathogens: community-acquired invasive infections caused by ceftriaxone- and ciprofloxacin-resistant Salmonella enterica serotype choleraesuis

Clin Infect Dis. 2005 Jan 15;40(2):315-8. doi: 10.1086/426593. Epub 2004 Dec 21.

Abstract

Recently, antimicrobial resistance among nontyphoid Salmonella serotypes has been increasingly recognized. In southern Taiwan, we encountered 3 cases of invasive infections caused by Salmonella enterica serotype Choleraesuis with resistance to ciprofloxacin and ceftriaxone. Resistance to ciprofloxacin was related to nucleotide mutations in gyrA and parC, and resistance to ceftriaxone was related to the presence of CMY-2 beta -lactamase.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Bacteremia / drug therapy
  • Bacteremia / microbiology
  • Ceftriaxone / pharmacology*
  • Ciprofloxacin / pharmacology*
  • Community-Acquired Infections / drug therapy
  • Community-Acquired Infections / microbiology*
  • DNA Gyrase
  • DNA Topoisomerase IV
  • Drug Resistance, Multiple, Bacterial*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Salmonella / drug effects*
  • Salmonella / genetics
  • Salmonella Infections / drug therapy
  • Salmonella Infections / microbiology*
  • Taiwan / epidemiology
  • beta-Lactamases

Substances

  • Anti-Bacterial Agents
  • Ciprofloxacin
  • Ceftriaxone
  • beta-lactamase CMY-2
  • beta-Lactamases
  • DNA Topoisomerase IV
  • DNA Gyrase