Abstract
The behavioral effects produced by MK-801 (0.4 mg/kg) were compared in mutant DAO-/- mice lacking D-amino acid oxidase activity and normal DAO+/+ mice. Mutant mice display marked diminution of stereotypy and ataxia induced by MK-801 compared to normal mice. Because the D-serine level in the brain of mutant mice is significantly higher than that of normal mice, the elevated D-serine in the brain of mutant mice could antagonize MK-801-induced stereotypy and ataxia.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Ataxia / chemically induced
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Ataxia / enzymology*
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Ataxia / genetics
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D-Amino-Acid Oxidase / deficiency*
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D-Amino-Acid Oxidase / genetics
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Dizocilpine Maleate / toxicity*
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Locomotion / drug effects
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Locomotion / physiology
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Male
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Mice
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Mice, Mutant Strains
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Stereotyped Behavior / drug effects
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Stereotyped Behavior / physiology*
Substances
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Dizocilpine Maleate
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Dao1 protein, mouse
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D-Amino-Acid Oxidase