Abstract
We assessed the impact of chronic swim stress in rats (daily for 3 weeks) on vesicular monoamine transporter 2 (VMAT2) in the nucleus accumbens and striatum. Exposure to repeated swim stress resulted in significant reduction in VMAT2 density in nucleus accumbens (20%, p<0.01) and striatum subregions (21-38%, p<0.001). The down-regulation of VMAT2 in this dopaminergic regions may serve as an adaptatory mechanism in the response to prolonged stress, and may be relevant to chronic stress-induced depression.
MeSH terms
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Animals
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Corpus Striatum / metabolism*
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Corpus Striatum / physiology
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Down-Regulation / physiology*
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Male
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Membrane Glycoproteins / antagonists & inhibitors*
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Membrane Glycoproteins / biosynthesis*
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Membrane Transport Modulators*
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Membrane Transport Proteins / antagonists & inhibitors*
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Membrane Transport Proteins / biosynthesis*
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Nucleus Accumbens / metabolism*
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Nucleus Accumbens / physiology
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Physical Exertion / physiology*
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Protein Binding / physiology
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Rats
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Stress, Physiological / metabolism*
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Stress, Physiological / psychology
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Swimming / physiology
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Time Factors
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Vesicular Biogenic Amine Transport Proteins
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Vesicular Monoamine Transport Proteins
Substances
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Membrane Glycoproteins
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Membrane Transport Modulators
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Membrane Transport Proteins
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Slc18a2 protein, rat
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Vesicular Biogenic Amine Transport Proteins
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Vesicular Monoamine Transport Proteins