High viral loads of human papillomavirus predict risk of invasive cervical carcinoma

M Moberg; I Gustavsson; E Wilander; U Gyllensten

doi:10.1038/sj.bjc.6602436

High viral loads of human papillomavirus predict risk of invasive cervical carcinoma

Br J Cancer. 2005 Mar 14;92(5):891-4. doi: 10.1038/sj.bjc.6602436.

Authors

M Moberg¹, I Gustavsson, E Wilander, U Gyllensten

Affiliation

¹ Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala 751 85, Sweden.

Abstract

High loads of human papillomavirus (HPV) 16 and HPV 18/45 increase the risk of developing invasive cervical carcinoma, revealing higher risk in percentiles of highest viral loads for HPV 16 (odds ratio (OR) 58.7, 95% confidence interval (CI) 21.9-151.4) compared to HPV 18/45 (OR 3.3, 95% CI 1.5-7.2). Thus, HPV load is a type-dependent risk marker for invasive carcinoma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / virology
DNA, Neoplasm / genetics
Female
Humans
Middle Aged
Neoplasm Invasiveness
Odds Ratio
Papillomaviridae / isolation & purification*
Risk Factors
Uterine Cervical Neoplasms / pathology*
Uterine Cervical Neoplasms / virology
Vaginal Smears
Viral Load*

Substances

DNA, Neoplasm