DTPA-bisamide-based MR sensor agents for peroxidase imaging

Manuel Querol; John W Chen; Ralph Weissleder; Alexei Bogdanov Jr

doi:10.1021/ol050208v

DTPA-bisamide-based MR sensor agents for peroxidase imaging

Org Lett. 2005 Apr 28;7(9):1719-22. doi: 10.1021/ol050208v.

Authors

Manuel Querol¹, John W Chen, Ralph Weissleder, Alexei Bogdanov Jr

Affiliation

¹ Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.

PMID: 15844889
DOI: 10.1021/ol050208v

Abstract

[reaction: see text] The synthesis and some properties of two novel DTPA-bisamides are reported. These derivatives were designed as enzyme-activated contrast agents (CA) for magnetic resonance imaging. Both derivatives bear tyramido or 5-hydroxytryptamido groups that could be oligomerized in situ in the presence of peroxidase/H(2)O(2) pair resulting in a net increase in longitudinal (R1) relaxivity.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Contrast Media* / chemical synthesis
Contrast Media* / chemistry
Gadolinium DTPA / chemistry
Magnetic Resonance Imaging*
Pentetic Acid / analogs & derivatives
Pentetic Acid / chemical synthesis*
Pentetic Acid / chemistry
Peroxidases / metabolism*

Substances

Contrast Media
Pentetic Acid
Peroxidases
Gadolinium DTPA

Grants and funding

1RO1EB00858/EB/NIBIB NIH HHS/United States