Abstract
The recent characterization of the choline carrier of the malaria parasite and its role in the selective delivery of novel antimalarial drugs has reignited interest in parasite transporters as a drug-delivery strategy. In this article, we discuss these findings in relation to the wider context of developing a sustainable antimalarial-drug-development portfolio.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antimalarials / administration & dosage*
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Antimalarials / pharmacokinetics
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Cell Membrane / metabolism
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Erythrocytes / metabolism
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Erythrocytes / parasitology*
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Haplorhini
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Humans
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Malaria / blood
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Malaria / drug therapy*
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Membrane Transport Proteins / metabolism*
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Plasmodium / metabolism*
Substances
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Antimalarials
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Membrane Transport Proteins
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choline transporter