Abstract
The thiophene-, benzothiazole- and pyridine-thioaryloxyacids analogues of clofibric acid were synthesized and their antiplatelet activity was screened. Some compounds exhibited antiaggregating properties. The platelet-related haemostasis was measured on a PFA-100 analyzer using bull blood.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cattle
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Clofibric Acid / analogs & derivatives
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Clofibric Acid / chemical synthesis*
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Clofibric Acid / pharmacology*
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Hypolipidemic Agents / chemical synthesis
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Hypolipidemic Agents / chemistry
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Hypolipidemic Agents / pharmacology
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Platelet Aggregation / drug effects*
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Thiazoles / chemical synthesis
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Thiazoles / pharmacology*
Substances
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Hypolipidemic Agents
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Thiazoles
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Clofibric Acid