Abstract
The water soluble oxovanadium(IV) tetraarylporphyrin has demonstrated excellent solution stability against glutathione reduction and high potency (5 microM, 97% inhibition) in inhibiting HIV-1 replication in Hut/CCR5 cells.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-HIV Agents / chemistry*
-
Anti-HIV Agents / pharmacology
-
Cell Line
-
Dose-Response Relationship, Drug
-
Drug Stability
-
Glutathione / metabolism
-
Humans
-
Metalloporphyrins / chemistry
-
Metalloporphyrins / pharmacology*
-
Oxidation-Reduction
-
Receptors, CCR5
-
Solubility
-
Vanadium Compounds / chemistry
-
Vanadium Compounds / pharmacology*
-
Virus Replication / drug effects
Substances
-
Anti-HIV Agents
-
Metalloporphyrins
-
Receptors, CCR5
-
Vanadium Compounds
-
Glutathione