Abstract
Mixed cationic liposomes composed by different ratios of dimyristoyl-sn-glycero-phosphatidylcoline (DMPC) and a cationic gemini surfactant have been studied by various physicochemical tools as vehicles for m-tetrahydroxyphenylchlorin (m-THPC), a photosensitizer used in photodynamic therapy. Entrapment and location of m-THPC within the lipid double layer have been evaluated by different techniques and the new formulations have been tested on a stabilized cell line from a human colon tumor, COLO206. A correlation between the physicochemical features of formulations and their efficiency as photosensitizers vector was found.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cations
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Cell Line, Tumor
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Dimyristoylphosphatidylcholine / chemistry*
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Fluorescence
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Humans
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Light
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Liposomes / chemistry*
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Mesoporphyrins / administration & dosage
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Mesoporphyrins / chemistry
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Mesoporphyrins / pharmacology
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Microscopy, Confocal
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Microscopy, Electron, Transmission
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Photochemotherapy
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Photosensitizing Agents / administration & dosage
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / pharmacokinetics*
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Quaternary Ammonium Compounds / chemistry*
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Scattering, Radiation
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Succinates / chemistry*
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Surface-Active Agents / chemistry*
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Transition Temperature
Substances
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2,3-bis((dimethyl(pentadecyl)ammonio)methyl)succinic acid
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Cations
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Liposomes
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Mesoporphyrins
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Photosensitizing Agents
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Quaternary Ammonium Compounds
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Succinates
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Surface-Active Agents
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temoporfin
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Dimyristoylphosphatidylcholine