Donor cell derived acute myeloid leukemia after allogeneic cord blood transplantation in a patient with adult T-cell lymphoma

Am J Hematol. 2005 Aug;79(4):294-8. doi: 10.1002/ajh.20349.

Abstract

We report a patient with adult T-cell lymphoma who developed acute myeloid leukemia (AML) after allogeneic cord blood transplantation (CBT). Fluorescence in situ hybridization (FISH) studies and molecular analysis using short tandem repeat (STR) sequences proved the AML to be of donor origin. Although 25 cases of donor cell leukemia (DCL) occurring after allogeneic bone marrow transplantation have previously been reported, there have been no reports of DCL after CBT. This case is the first-reported DCL patient after CBT.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Chromosomes, Human, X / genetics
  • Chromosomes, Human, Y / genetics
  • Cord Blood Stem Cell Transplantation*
  • Fatal Outcome
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leukemia, Myeloid / etiology*
  • Leukemia, Myeloid / genetics
  • Lymphoma, T-Cell / therapy*
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / etiology*
  • Neoplasms, Second Primary / genetics
  • Tandem Repeat Sequences
  • Tissue Donors
  • Transplantation Chimera
  • Transplantation, Homologous