Abstract
Hydrazide-containing bifunctional nanospheres were covalently coupled on the surface with IgG, avidin, and biotin, to generate novel fluorescent-magnetic-biotargeting trifunctional nanospheres, which can be used in a number of biomedical applications, including visual sorting and manipulation of apoptotic cells as demonstrated here.
Publication types
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Annexin A5
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Apoptosis / radiation effects
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Avidin / chemistry
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Biotin / chemistry
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Chromatography, Liquid
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Fluorescein-5-isothiocyanate
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Fluorescent Dyes / chemistry*
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HeLa Cells
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Humans
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Immunoglobulin Fc Fragments
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Immunoglobulin G / chemistry
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Magnetics
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Nanoparticles / chemistry*
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Ultraviolet Rays
Substances
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Aldehydes
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Annexin A5
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Fluorescent Dyes
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Immunoglobulin Fc Fragments
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Immunoglobulin G
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Avidin
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Biotin
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Fluorescein-5-isothiocyanate