Dose proportionality study of loperamide following oral administration of loperamide oxide

Eur J Clin Pharmacol. 1992;42(6):693-4. doi: 10.1007/BF00265940.

Abstract

The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Analysis of Variance
  • Biological Availability
  • Biotransformation
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Humans
  • Loperamide / administration & dosage
  • Loperamide / analogs & derivatives*
  • Loperamide / blood
  • Loperamide / pharmacokinetics
  • Male

Substances

  • Loperamide
  • loperamide oxide