Abstract
The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Administration, Oral
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Adult
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Analysis of Variance
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Biological Availability
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Biotransformation
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Dose-Response Relationship, Drug
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Double-Blind Method
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Humans
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Loperamide / administration & dosage
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Loperamide / analogs & derivatives*
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Loperamide / blood
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Loperamide / pharmacokinetics
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Male
Substances
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Loperamide
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loperamide oxide