What else has to happen for nitric oxide to induce cell death?

Biochem Soc Trans. 2005 Dec;33(Pt 6):1394-6. doi: 10.1042/BST0331394.

Abstract

Nitric oxide (NO) can induce cell death; however, NO-induced cell death may be dependent/conditional on factors other than NO itself. Whether NO kills a particular cell depends on the amount of NO, source of NO, time of exposure to NO, cell type and the levels of other factors including, particularly oxygen, superoxide, H2O2, antioxidants, thiols and glycolysis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / metabolism
  • Cell Death / physiology*
  • Glutathione / metabolism
  • Glycolysis / physiology
  • Nitric Oxide / metabolism*
  • Nitric Oxide Synthase / metabolism
  • Oxidants / chemistry
  • Oxidants / metabolism
  • Oxygen / metabolism
  • Superoxides / chemistry
  • Superoxides / metabolism

Substances

  • Antioxidants
  • Oxidants
  • Superoxides
  • Nitric Oxide
  • Nitric Oxide Synthase
  • Glutathione
  • Oxygen