The regulation of cell migration by PTEN

N R Leslie; X Yang; C P Downes; C J Weijer

doi:10.1042/BST0331507

The regulation of cell migration by PTEN

Biochem Soc Trans. 2005 Dec;33(Pt 6):1507-8. doi: 10.1042/BST0331507.

Authors

N R Leslie¹, X Yang, C P Downes, C J Weijer

Affiliation

¹ Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, Scotland, UK. n.r.leslie@dundee.ac.uk

PMID: 16246156
DOI: 10.1042/BST0331507

Abstract

In vertebrates, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) regulates many cellular processes through its PtdIns(3,4,5)P3 lipid phosphatase activity, antagonizing PI3K (phosphoinositide 3-kinase) signalling. Given the important role of PI3Ks in the regulation of directed cell migration and the role of PTEN as an inhibitor of migration, it is somewhat surprising that data now indicate that PTEN is able to regulate cell migration independent of its lipid phosphatase activity. Here, we discuss the role of PTEN in the regulation of cell migration.

Publication types

Review

MeSH terms

Animals
Cell Movement / physiology*
Humans
PTEN Phosphohydrolase / genetics
PTEN Phosphohydrolase / metabolism*
Phosphatidylinositol 3-Kinases / metabolism
Phosphatidylinositol Phosphates / metabolism

Substances

Phosphatidylinositol Phosphates
phosphatidylinositol 3,4,5-triphosphate
Phosphatidylinositol 3-Kinases
PTEN Phosphohydrolase