VLA molecule expression may be involved in the release of acute myeloid leukaemic cells from the bone marrow

I A Denkers; T J de Jong-de Boer; R H Beelen; G J Ossenkoppele; M M Langenhuijsen

doi:10.1016/0145-2126(92)90172-4

VLA molecule expression may be involved in the release of acute myeloid leukaemic cells from the bone marrow

Leuk Res. 1992;16(5):469-74. doi: 10.1016/0145-2126(92)90172-4.

Authors

I A Denkers¹, T J de Jong-de Boer, R H Beelen, G J Ossenkoppele, M M Langenhuijsen

Affiliation

¹ Department of Haematology, Free University, Amsterdam, The Netherlands.

PMID: 1625472
DOI: 10.1016/0145-2126(92)90172-4

Abstract

Acute myeloid leukaemia (AML) cells have a variable capacity to egress from bone marrow into peripheral blood. This may be due to a variable lack of adhesion molecules on leukaemic cells. The expression of VLA1, 3, 4, 5, 6, beta 1-chain, LFA1, beta 2-chain, ICAM1 and NCAM appeared to be higher in bone marrow as compared to peripheral blood leukaemic cells, although this only reached significance for beta 1-chain (p less than 0.01). The number of cases with more than 20% positive cells in bone marrow leukaemic cells was lower in immature FAB-subtypes (M1, M5a) as opposed to more mature subtypes (M2, M3, M4, M5b) for the adhesion molecules tested. This reached significance for VLA5 (p less than 0.05) and beta 1-chain (p less than 0.007), while there was trend for VLA4. It is discussed that VLA4 and 5 may play a role in the release of leukaemic cells from the bone marrow.

MeSH terms

Acute Disease
Bone Marrow / metabolism*
Bone Marrow / pathology
Cell Adhesion Molecules / metabolism*
Humans
Leukemia, Myeloid / metabolism*
Leukemia, Myeloid / pathology
Receptors, Very Late Antigen / metabolism

Substances

Cell Adhesion Molecules
Receptors, Very Late Antigen