Virus-host interactions: new insights from the small RNA world

Genome Biol. 2005;6(11):238. doi: 10.1186/gb-2005-6-11-238. Epub 2005 Oct 31.

Abstract

RNA silencing has a known role in the antiviral responses of plants and insects. Recent evidence, including the finding that the Tat protein of human immunodeficiency virus (HIV) can suppress the host's RNA-silencing pathway and may thus counteract host antiviral RNAs, suggests that RNA-silencing pathways could also have key roles in mammalian virus-host interactions.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Products, tat / metabolism*
  • HIV / metabolism
  • HIV / pathogenicity
  • HIV Infections / genetics
  • HIV Infections / virology
  • MicroRNAs / metabolism
  • Models, Genetic
  • RNA Interference / physiology*
  • RNA, Small Interfering / metabolism
  • RNA, Viral / metabolism*
  • Virus Diseases / genetics
  • Virus Diseases / virology*
  • tat Gene Products, Human Immunodeficiency Virus

Substances

  • Gene Products, tat
  • MicroRNAs
  • RNA, Small Interfering
  • RNA, Viral
  • tat Gene Products, Human Immunodeficiency Virus