Abstract
RNA silencing has a known role in the antiviral responses of plants and insects. Recent evidence, including the finding that the Tat protein of human immunodeficiency virus (HIV) can suppress the host's RNA-silencing pathway and may thus counteract host antiviral RNAs, suggests that RNA-silencing pathways could also have key roles in mammalian virus-host interactions.
MeSH terms
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Animals
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Gene Products, tat / metabolism*
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HIV / metabolism
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HIV / pathogenicity
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HIV Infections / genetics
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HIV Infections / virology
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MicroRNAs / metabolism
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Models, Genetic
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RNA Interference / physiology*
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RNA, Small Interfering / metabolism
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RNA, Viral / metabolism*
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Virus Diseases / genetics
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Virus Diseases / virology*
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tat Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, tat
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MicroRNAs
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RNA, Small Interfering
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RNA, Viral
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tat Gene Products, Human Immunodeficiency Virus