Abstract
A series of 29 new quinoxalines was synthesized and evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, and Trichomonas vaginalis). Several of them displayed interesting activities, and particularly four quinoxaline amides showed in vitro antileishmanial properties (IC50 less than 20 microM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / chemical synthesis*
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / pharmacology*
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In Vitro Techniques
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Leishmania donovani / drug effects
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Molecular Structure
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Parasitic Sensitivity Tests
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Quinoxalines / chemical synthesis*
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Quinoxalines / chemistry
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Quinoxalines / pharmacology*
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Structure-Activity Relationship
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Trichomonas vaginalis / drug effects
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Trypanosoma brucei brucei / drug effects
Substances
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Antiprotozoal Agents
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Quinoxalines