We report a case of Osteogenesis Imperfecta (OI) in an eight-year-old boy who was admitted with complaints of recurrent long bone fractures. With oral alendronate treatment significant increment occurred in the bone mineral density and the number of fractures decreased. The usage of oral bisphosphonates is inexpensive and easy to administer in selected cases of OI. This case report supports the usage of oral alendronate treatment as an alternative treatment in OI.